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R37AI049954 (to G.C.T)

However, iron chelators including deferoxamine (DFO), deferiprone (DFP), and deferasirox (DFX) generally lack tissue and cellular specificity, often resulting in the non-selective depletion of physiologically essential iron

Although fetal and maternal plasma concentrations of vitamin B-12 are reported to correlate strongly (34), some suggest that maternal dietary intake during pregnancy is a stronger determinant of infant vitamin B-12 status than are maternal vitamin B-12 stores (35)

This finding reinforces my philosophy that individualized medicine is crucialwe must consider not just the primary genetic defect but also the supporting cast of genes that influence how our bodies handle oxidative stress