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In a healthy heart, Ca 2+ enters cardiomyocytes during each heartbeat predominantly through L-type Ca 2+ channels, triggering the release of additional Ca 2+ from the sarcoplasmic reticulum (SR)

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Lactate metabolic reprogramming mediated by CircRNA-LDHA complex facilitates innate immune evasion of liver cancer

If a patient experiences several of these factors together, they may synergize to produce critical hyperammonemia
