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In activated microglial cells, P2X7 is directly involved in triggering the production of TNF cytokine that can be involved in the process of neuronal death both through apoptosis and through necroptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] Ramani M, Miller K, Brown J, Kumar R, Kadasamy J, McMahon L, et al

This often leads to high background noise, complicating the identification of specific interactions

?, uncertain) Demographics reported Medical comorbidities reported Excluded medical comorbidities Non- retrospective design Standardized criteria used for diagnosis Reported medication use Excluded use of antioxidants Representative population First author Year General risk of bias items Brain GSH Duy 2014 +-+ + + + -+ Mandal 2015 +-+ + + - - + Marjanska 2019 +-+ + + - - + Mullins 2018 +-+ + + - -