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Cancer cells acquire a diverse range of metabolic flexibility and plasticity as an adaptation to ever-changing nutritional microenvironments during tumor evolution [13]
We also show the total chemical synthesis of an activity-based probe of ubiquitinated histone H2A at Lys119 to prepare ubiquitinated nucleosome core particle probes (NCP-(H2A-Ub DHA ))
This is corroborated by numerous animal models
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