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Description
Pharmacological evaluation in obesity-induced rats revealed that a BBB penetrant inverse agonist for the GHSR-1a effectively reduced weight gain [334]
Promotes skin lightening and reduces dullness
Metformin exerts its antitumor effects mainly through the AMPK/LKB1/mammalian target of rapamycin (mTOR) complex 1 (mTORC1) signaling pathway, causing apoptosis of cancer cells (4548)
Given that LCL-161 is currently undergoing phase 2 clinical trials for MM, these findings suggest that SMs may offer additional clinical benefits by mitigating bone degradation in myeloma patients (8)
