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Inflammation also shifts tryptophan metabolism away from serotonin to neurotoxic kynurenine pathway metabolites, like quinolinic acid, and disturbs neurotransmission and thus plays a role in depressive symptoms (Liang et al., 2024)

Moreover, they facilitate the storage and transmission of forces to the skeletal system during movement

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Despite significant progress with various brain targeting ligands, research on using the Na + -dependent GSH transporter for brain targeting has been limited and deserves more attention considering the unique organ selective distribution of the transporter in the brain