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In addition, we obtained a healthy male donor-derived hiPSC line KOLF 2.1J 35 and an isogenic line harboring the PD-associated DJ1 L166P LOF point mutation

Protein lipoylation is a key post-translational modification involving the covalent attachment of an acyl group (e.g., acetyl, propionyl, succinyl, etc.) to specific amino acid residues, most commonly the -amino group of lysine (Solmonson and DeBerardinis, 2018

Thus, oxidative damage to mtDNA may play a critical role in neurodegeneration in AD brain, including its prodromal stages

doi:10.1089/ars.2019.7971 Tang, W H Wilson et al
