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J Clin Endocrinol Metab 81 : 24742480 Sermet-Gaudelus I et al

Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those using diuretics concomitantly and the elderly

These antioxidative properties seem to enhance lifespan of the three kinds of animals mentioned above

Together, these findings suggest that circadian susceptibility in asthma may reflect impaired temporal coordination and intracellular competence of innate immune cells to execute melatonin-dependent redox buffering programs and identify the NRF2 glutathione axis as a therapeutically actionable pathway