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PGE 2 contributes to pain hypersensitivity and hyperalgesia by lowering pain thresholds and by enhancing nociceptor sensory fiber excitability by activating EP1-EP4 receptors on nociceptors [91,112]

Using this approach, the current study also deployed two additional lytic phages that bind to LPS (phage LPS-5) or to TIVP (phage TIVP-H6), which drive evolved phage resistance trade-offs that compromise bacterial virulence

Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, et al

DKD: Diabetic kidney disease AKI: Acute kidney injury ROS: Reactive oxygen species TFR1: Transferrin receptor 1 FTH1: Ferritin heavy chain LOXs: Lipoxygenases NCOA4: Nuclear receptor coactivator 4 RTECs: Renal tubular epithelial cells AA: Arachidonic acid PUFAs: Polyunsaturated fatty acids ACSL4: Acyl-CoA synthetase long chain family member 4 NADPH: Nicotinamide adenine dinucleotide phosphate System Xc - : Cystine/glutamate antiporter system GSH: Glutathione GPX4: Glutathione peroxidase 4 FSP1: Ferroptosis suppressor protein 1 Nrf2: Nuclear factor erythroid 2-related factor 2 AMPK: AMP-activated protein kinase ALOX: Arachidonate lipoxygenase TGF-1: Transforming growth factor beta 1 NF-B: Nuclear factor-B VDACs: Voltage-dependent anion channel 2/3 HO-1: Heme oxygenase-1 HMGB1: High mobility group 1 FPN: Ferroportin IRI: ischemia-reperfusion injury N.A.: Not applicable This study was financially supported by the National Natural Science Foundation of China Joint Project (No