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Then, it was centrifuged at 18,000 g for 20 min at 4C

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High orotic acid levels can be caused by: Arginine deficiency [3, 4, 6] Refeeding after fasting [7] Impaired liver function due to alcohol, drugs (such as valproic acid), liver disease or viral liver infection [8, 5, 9, 10, 11, 12] Physical trauma [13] Inborn errors of urea cycle metabolism [4, 14] If your levels are abnormal, work with your doctor to find out whats going on in order to properly treat the underlying condition

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