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Finally, a PAM agent like pomaglumetad which is a presynaptic mGluR 2/3 agonist, could have been expected to reduce glutamate release when synaptic concentrations are high and increase them when they are low, a goal not inconsistent with 1 H-MRS findings
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Sermorelin is FDA-approved only for pediatric GH deficiency
Patients in advanced stages are mostly treated with combination therapy based on DDP or fluoropyrimidines [3, 34]
