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The reduction reaction is catalysed by redoxin enzymes, such as TRXs and GRXs that transfer reducing equivalents from the PET chain as well as from NAPDH, GSH, and ascorbate
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J Pharm Pharmacogn Res 9:366378 Mukai E, Fujimoto S, Inagaki N (2022) Role of reactive oxygen species in glucose metabolism disorder in diabetic pancreatic -cells
Some experience mild detoxification symptoms as cellular glutathione elevation supports toxin mobilization, though proper hydration and lifestyle support help minimize these effects
