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Also, similarly to ET, 2-AAPA treatment alleviated ER stress, as determined by attenuated Xbp1 splicing (Figure 3B) and diminished upregulation of UPR target genes (Figure 3C)
Insulin sensitivity and glucose handling
422 However, it is unclear whether the role of MT in controlling the MST1/LATS2/YAP1 signaling pathway depends on its regulation of zinc
These pathways are not only well-characterized mediators of inflammatory and oxidative responses but also serve as upstream modulators of ferroptosis across diverse disease contexts, including pulmonary, musculoskeletal, and renal systems
