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First-generation SSAs (for example, lanreotide and octreotide) have a greater affinity for SSR2 than the SSR5 isoform of the somatostatin receptor(16)

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Kloppenburg M, Namane M, Cicuttini F

Researchers are exploring various drug delivery strategies, such as liposomal formulations, nanoencapsulation, and prodrug strategies, to improve the bioavailability and targeted delivery of senomorphic compounds to specific tissues affected by senescence.196 Potential Off-Target Effects: While senomorphic compounds are designed to modulate the senescence process without clearing senescent cells completely, there is a risk of unwanted off-target effects.197 Senescence plays a protective role in certain contexts, such as tumor suppression and wound healing