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Description
Increased expression of glutamate-cysteine ligase catalytic subunit (GCLC) and solute carrier family 7 member 11 (SLC7A11) can regulate GSH metabolism, promote GSH synthesis, and markedly increase the proliferation of Waldenstrom macroglobulinemia cells [8]

They found that among 46 -glutamyl peptides, glutathione (-glutamyl-cysteinyl-glycine) and -glutamyl-valinyl-glycine (-Glu-Val-Gly) were very strong calcium-sensing receptor (CaSR) agonists that increased the kokumi flavor of chicken consomm and enhanced sweet, salty, and umami tastes independently when added to aqueous solutions of sucrose, NaCl, and MSG, respectively, in human sensory tests

This is followed by maintenance injections of 1mg every 2-3 months (or every 2 months with neurological involvement)

Senescence is triggered by various intrinsic and extrinsic factors, including DNA damage, telomere attrition, oncogene activation, and oxidative stress, as illustrated in Figure 1
