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They may also be involved in other vasoregulatory systems such as the RAS and H 2 S pathway, and provide renal-protective effects

In terms of neurodevelopment, excessive FA supplementation is associated with impaired neurocognitive development in children, which may lead to poor psychomotor development and an increased risk of autism [153]

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Mechanistically, butyrate can increase the quantity of the serotonin-derived metabolite 5-hydroxyindole-3-acetic acid (5-HIAA), which binds to the Aryl Hydrocarbon receptor (AhR)