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Description
We have produced a large-scale computational biology analysis of the SNO-proteome in the cortex of Shank3 mutant mice (a popular model of ASD [171, 282, 283]) and found that among the NO-related molecular alterations, the most prominent change was the activation of the mTOR signaling pathway [171, 176]

ROS are known to cause DNA damage and OS, leading to sperm damage when cellular antioxidant defenses are overwhelmed

HY: Methodology, Project administration, Writing review & editing

JHU395 can prolong the median survival of mice bearing human MYC-amplified medulloblastoma xenografts from 26 to 45 days (Pham et al., 2021)
