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Simultaneously, within the ischemic penumbra, the activation of platelets and the complement system, as well as the release of inflammatory mediators, induce metabolic pathways to overcompensate for ischemic damage, leading to an excessive release of ROS [69, 70]

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doi: 10.1016/j.brainresbull.2021.07.016 213 BizziABrooksRABrunettiAHillJMAlgerJRMiletichRSet al

doi: 10.3389/fped.2025.1514722 Received 21 October 2024 Accepted 03 January 2025 Published 27 January 2025 Volume 13 - 2025 Edited by Sachith Mettananda, University of Kelaniya, Sri Lanka Reviewed by Nishant Chakravorty, Indian Institute of Technology Kharagpur, India J.W