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Tiequn B, Guanqun C, Shuo Z
The ratio of GSH/GSSG (antioxidant capacity) ensures the reducing intracellular environment that is required for normal immunity function
Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded
Our systematic review and meta-analysis had several strengths
