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The significant decrease in ROS-mediated tube formation and wound healing in human microvascular endothelial cells (HMECs) after siRNA-mediated NOX4 knockdown further underscores its crucial role in angiogenesis and endothelial cell proliferation [51]

In the liver, it may be transformed into glucose and stored as glycogen, while consuming hydrogen ions to help maintain bicarbonate levels and enhance extracellular pH buffering [233]

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

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