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Both in vitro and in vivo studies showed that knockdown of either the H or L subunits of ferritin in GBM CSCs markedly reduced cellular growth, as well as their capacity to form tumors in orthotopic models, which supports the role of ferritin as a key player in the proliferation and invasion of CSCs [3]

Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, et al

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In a study of serum trace elements in schizophrenia ( n = 11) and BD patients ( n = 7 lithium treated and n = 8 lithium non-treated), serum iron was significantly high in BD patients without lithium treatment compared to the healthy controls ( n = 11) [120]