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High-fat diet induces disruption of the tight junction-mediated paracellular barrier in the proximal small intestine before the onset of type 2 diabetes and endotoxemia
The goal: to maximize therapeutic potential through synergy between components
Impaired binding could explain altered integrin mechanotransduction in degenerated discs 28 , and also the presence of fibronectin fragments in the matrix which have been shown to induce catabolic changes in disc cells 48
