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Since vitamin B 12 is a determinant of homocysteine metabolism, it was suggested that the risk of osteoporotic fractures in older subjects might be enhanced by vitamin B 12 deficiency

Improvement of insulin sensitivity: The peptide may help regulate blood glucose levels and improve insulin response

doi: 10.3389/fnut.2025.1701661 Received 08 September 2025 Revised 10 November 2025 Accepted 04 December 2025 Published 05 January 2026 Volume 12 - 2025 Edited by Emanuele Micaglio, IRCCS San Donato Polyclinic, Italy Reviewed by Runzhe Xu, University of Texas Southwestern Medical Center, United States Husain Alkhaldy, King Khalid University, Saudi Arabia Updates Copyright 2026 de Carvalho, Akamine, Di Pietro, Frana, Oliveira and Lopes

These data suggest that the increased risk of anemia observed in patients with T2D treated with metformin cannot be explained by vitamin B12 deficiency