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This is particularly significant for patients with premature ovarian failure, as oxidative stress is a critical factor contributing to ovarian dysfunction

They prevent excessive immune activation and suppress autoreactive T cells that would otherwise attack the body own tissues

Though the disruption of cytosolic cysteine metabolism (i.e., GSH synthesis) plays a significant role in the induction of ferroptosis under cysteine limitation 5,19 , it remains unknown if alterations in mitochondrial cysteine metabolism are also operative

The central, hydrophobic, non-amyloid component (NAC) region of S has been described as highly aggregation prone and contains one of the minimal sequences needed for aggregation, S 71 82 , thought to be responsible for instigating aggregation of the full-length protein and therefore the focus of many early publications and attempts to inhibit S aggregation [52]