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It also impairs base and nucleotide excision repair pathways and causes widespread epigenetic dysregulation, such as aberrant DNA methylation and histone modification, that silence tumor suppressor genes [176]

Striatal and extrastriatal dopamine D2 receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [C]raclopride and [C]FLB457

Both direct antioxidant actions and SIRT1-mediated deacetylation accomplish this

Importantly, the first committed step of the pathway, catalyzed by glucose-6-phosphate dehydrogenase (G6PD), is inhibited by NADPH [57]