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Major genes such as cytochrome P450 monooxygenase (CYP1A), Cytochrome b-245 light chain (CYBA), Xanthine dehydrogenase (XDH), and Amine oxidase (flavin-containing) A (MAOA) play an important role in the elevation of ROS or oxidative stress by inducing the expression of NOX3 to form a functional NADPH oxidase, which generates superoxide and other oxidants that are generally repressed by the adaptive response [47]

Still, some studies have found cold brew to be slightly less acidic, which means it may irritate your stomach less ( Another reason why this beverage may be less irritating than hot coffee is its content of crude polysaccharides

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