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K.SimonA.SteinA.et al (2020)
doi: 10.1038/s43018-022-00456-0 313 DasRHardieJJoshiBPZhangXGuptaALutherDCet al
Diets high in 6 polyunsaturated fatty acids (e.g., linoleic and arachidonic acid found in oils) enrich adipocyte membranes with precursors for pro-inflammatory eicosanoids (for instance, PGE 2 from arachidonate), which yield signals activating ERK/PI3K pathways 364
It appears that old age per se is not a risk factor for APAP toxicity, however, co-morbidities with impaired liver function, low body weight, polypharmacy, etc
