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Ferroptosis suppressor protein 1 (FSP1) was identified almost simultaneously by Bersuker et al
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Oxidative stress may also down-regulate other essential enzyme systems associated with the methionine cycle, including methionine synthase, betaine-homocysteine methyltransferase and methionine adenosyltransferase, leading to further monoamine neurotransmitter disruption and weakening of antioxidant enzyme activities (Guildford)
