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[DOI] [PubMed] [Google Scholar] 65.Ghiselli A., Serafini M., Maiani G., Azzini E., Ferro-Luzzi A
The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]
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Furthermore, myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and dysfunctional dendritic cells further impede CTL activity
