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The CML development has been associated with the cytogenetic change t(9,22)(q34, q11) resulting in the formation of the BCR-ABL1 gene fusion [59, 60]

Additionally, molecular analysis indicated that up-regulation of -arrestin2, an intracellular protein involved in the desensitization and internalization of dopamine receptors and activation of alternative signaling pathways, may be associated with reduced severity of dyskinesia in levodopa-benserazide-loaded PLGA nanocarrier-treated PD rats

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