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Any significant changes in symptoms such as increased fatigue, yellowing of eyes or skin, abdominal pain, or unexplained bruising should prompt immediate medical consultation rather than self-treatment with supplements

Trdaniel, J., Boffetta, P., Saracci, R

10.1016/j.bbrc.2019.09.023 127 WangZ.LiM.LiuY.QiaoZ.BaiT.YangL.et al (2021)

The question whether GABA forming microbiota can alter plasma GABA is unresolved: two germ-free models employing metabolomics support this premise (97, 98) whereas another germ-free rodent study did not (99)