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R While Gilbert syndrome itself is considered benign, reduced UGT1A1 activity also impairs glucuronidation of drugs (irinotecan toxicity is dramatically increased in UGT1A1*28 homozygotes) and estrogens
Darmaun D, Smith SD, Sweeten S, Hartman BK, Welch S, Mauras N
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N.H.S.: UM1 CA186107, P01 CA87969, R01 CA49449, R01-CA67262, UM1 CA176726
