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While apoptosis is widely recognised as the primary form of melanocyte death in vitiligo, other forms of cell death such as oxeiptosis and ferroptosis have also been considered, primarily because of their close association with oxidative stress

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Dihexa-based compounds do not interact with central or peripheral AT1 receptors, are highly target specific, exhibit little interaction with cardiac channel proteins and hepatic CIP isoforms, and reveal no acute toxicity following a 6x effective dose of Dihexa