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[DOI] [PubMed] [Google Scholar] 54.Purucker E, Winograd R, Roeb E, Matern S
Indeed, subsequent experiments showed that longer treatments with either PIPLC or monoclonal antibodies to PrP C can cure infected cell cultures [Peretz 2001, Enari 2001], suggesting that, at least in ScN2a cells, re-internalized PrP C is the predominant substrate for conversion to PrP Sc , with little or no contribution from nascent PrP just coming up the secretory pathway
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The heterogeneity test revealed no differences between the studies (separately, I 2 =0, 0, 0, 41, 41 and 0%, respectively)
