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81 , 92 In primary cells from BM aspirates of MM cells, isatuximabinduced apoptosis without any addition of external crosslinking agents and independent of effector cells
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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions
