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Description
In colorectal cancer, KRAS-mutant tumors exhibit greater lactate production than wild-type tumors, and elevated lactate levels resulting from KRAS mutations sensitize tumor-specific cytotoxic CD8 + T cells to activation-induced cell death (AICD) by suppressing NF-B activity, thereby reducing their infiltration into the tumor microenvironment (302)
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Zhang CF, Wang LJ, Li SS, Yuan F, Guo FY
