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This includes inflammatory cell recruitment and release of immune-cell-derived cytokines, such as IL-6 (60, 61) and TNF (62) and bioactive enzymes, including MMPs (46), which may, in turn, promote vascular remodeling and stiffening processes, thus establishing a progressive vicious cycle

Possible Side Effects While GHK-Cu is generally regarded in research settings as a widely investigated regenerative and copper-binding peptide, observed responses may vary depending on dosage range, administration frequency, protocol duration, sensitivity, copper balance, and individual physiology

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