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Uncleared extracellular DNA (for example, microsomal-bound DNA) can be recognized as a danger signal activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and promoting type I interferon secretion to drive lupus-like autoimmunity (17-19)

Reduction of disulfide bond is catalyzed by Trx (Figure 3), tryparedoxin, or alkyl hydroperoxide reductase [179,185]

Naftidrofuryl-induced liver injury