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Descrito pela primeira vez em 1993 por Sikiri et al., apresenta notvel estabilidade qumica, mantendo a atividade biolgica mesmo no ambiente gastrointestinal cido uma propriedade que o distingue da maioria dos peptdeos teraputicos

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This effect is partly mediated through the modulation of key cell cycle regulators such as cyclin D1 and p21, which facilitates progression from the G1 to S phase

Since PBMCs can be obtained through minimally invasive methods, this characteristic has garnered clinical interest in investigating their potential to differentiate between stages of MASLD