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Our previous study found that inhibiting LOX activity (Anti-LOX) promoted tunica albuginea remodeling by reducing collagen crosslinking, which finally increased penile length by 10.54% for adult rats, this effect achieved 17.71% when Anti-LOX was combined to a mechanical force from VED (Anti-LOX + VED) 15

It is worth noting that injectable tirzepatide currently has the strongest evidence base

doi: 10.3389/fphys.2026.1760997 Received 04 December 2025 Revised 18 February 2026 Accepted 23 February 2026 Published 20 March 2026 Volume 17 - 2026 Edited by Lars Knudsen, Hannover Medical School, Germany Reviewed by Svetlana Guryanova, Institute of Bioorganic Chemistry (RAS), Russia Ana Maria Jaramillo, University of Kansas Hospital, United States Updates Copyright 2026 Costello and Birket