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[PMC free article: PMC5393153] [PubMed: 19075184] 45

Cysteinyl leukotrienes Leukotrienes C 4 , D 4 and E 4 are potent lipid mediators generated by oxidation of arachidonic acid released from membrane phospholipids and conjugated to glutathione, involving enzymes such as phospholipases, ALOX5 and LTC4S

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Various disease states are characterized by disturbed metal homeostasis, such as hemochromatosis (iron overload) and flavonoids in the presence of iron (or other redox metals) behave as prooxidants, increasing the total amount of ROS (Valko et al