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It does so by binding to harmful substances and facilitating their elimination
10.1016/j.cryobiol.2019.11.044 67
MASH/NAFLD: Given the liver fat-reducing effects of GLP-1 receptor agonism, orforglipron may be evaluated for metabolic dysfunction-associated steatohepatitis (MASH), a condition affecting an estimated 5-6% of the adult population for which effective oral therapies are urgently needed
Nrf2 inhibits LXRalpha-dependent hepatic lipogenesis by competing with FXR for acetylase binding
