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Abstract To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell phenotype

Harada K, Hwang H, Wang X, Abdelhakeem A, Iwatsuki M, Blum Murphy MA, Maru DM, Weston B, Lee JH, Rogers JE, Thomas I, Shanbhag N, Zhao M, Bhutani MS, Nguyen QN, Swisher SG , Ikoma N, Badgwell BD, Hofstetter WL, Ajani JA

This compound is typically synthesized using solid-phase peptide synthesis and purified through HPLC to achieve analytical purity appropriate for research and assay use

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