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These results suggest a link between GSH oxidation and Ero1 activity that, if not direct, could be through the reduction of nonnative disulphides or members of the PDI family
Safety considerations (hypercalcemia/mineral imbalance) apply to active agents and high-dose bolus regimens
Liver mitochondria from iron-deficient rats have decreased mitochondrial respiration efficiency [114], lower mitochondrial membrane potential and ATP production [113], and suppressed capacity for gluconeogenesis via phosphoenolpyruvate carboxykinase (PCK) [115]
Recent studies have also reported cognition deficits which, however, were also documented in children unaffected with konzo within the same study population 3
