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PTX-3 was found to be an independent inflammatory marker correlated with the presence of LV diastolic dysfunction and HFpEF ( Table 1 ).49 In the CANTOS trial, when canakinumab succeeded in lowering high-sensitivity CRP below 2 mg/l, the likelihood of HF hospitalisation was lower.50 This study did not discriminate between HFrEF and HFpEF, yet patients were old and had a high prevalence of obesity, diabetes and arterial hypertension

Clin Cancer Res 9:57565767 Madiraju P, Pande SV, Prentki M, Madiraju SR (2009) Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

Central sensitization: iImplications for the diagnosis and treatment of pain

doi: 10.1038/s41598-020-80291-4 112 WangSLiuGLiYPanY