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However, there are IGF-I receptors on the nonparenchymal cells[89, 90] and it has been reported that IGF-I stimulates both DNA synthesis[91, 92] and the production of hepatocyte growth factor (HGF) in hepatic stellate cells in vitro [87]

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Anti-Aging and Skin Health Enhances Skin Elasticity: IGF-1 LR3's cellular repair properties can improve skin firmness and elasticity, promoting a youthful appearance by encouraging collagen production

doi: 10.1002/eji.202350823 40 SteffenUSchettGBozecA
