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To counter this risk, the eye relies on multiple protective systems, including high levels of ascorbic acid (vitamin C) and glutathione

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If significant fibrosis is confirmed, patients should be referred to a specialist to perform liver biopsy and confirm the diagnosis histologically ( Chronic inflammation is the driving force for the onset and progression of fibrosis in NASH ( 4

The first box described by structural studies was the Clathrin box, which was crystallized with peptides from -arrestin-1 and AP-3 3a with the canonical mammalian motif (LX[D/E], where is any hydrophobic residue)