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In our study, we for the first time identified cancer driver genes and genes playing key roles in oncogenic pathways induced by CR perturbation of cellular composition, tissue homeostasis and metabolic reprogramming, leading to cell proliferation of epithelium mucosa and global depletion of immune system control

B12 deficiency can result in persistent fatigue, weakness, and slowing metabolism which can lead to weight gain

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10.1016/j.mehy.2007.02.037 Magin PJ, Adams J, Heading GS, Pond DC, Smith W: Complementary and alternative medicine therapies in acne, psoriasis, and atopic eczema: results of a qualitative study of patients' experiences and perceptions