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Future research should focus on the integration of multi-omics data, including proteomics, spatial transcriptomics, and metabolomics, in combination with AI-driven analyses

This situation was first reported in a boy with a deletion of exon 4 of the IGF-I gene (90) resulting in severe fetal and post-natal growth arrest, poor brain development and extreme insulin resistance with compensatory hyperinsulinemia and acanthosis nigricans

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Okamoto N, Yoshino K, Kitagawa S, Fujii R, Hamada S, Ikenouchi A, et al