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The specificity and effective in vivo concentrations of many natural products or small molecule agonists are debatable, with some effects possibly stemming from their broad-spectrum antioxidant capacity rather than genuine Nrf2-specific action

Theanine has been shown to increase cancer cell apoptosis and decrease cancer cell growth, decrease liver cirrhosis, decrease nephrotoxicity, and decrease vascular remodeling

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IGFBP-1: insulin-like growth factor-binding protein-1
